Proteomic, Spatial, and Multiomic Services

Carolina Molecular provides a comprehensive suite of proteomic, spatial, and multiomic services. By integrating cutting-edge technologies from industry-leading partners, we empower you to move from discovery to clinical insight, faster.

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Complex Biology, Simplified.

The next breakthrough in therapeutic development and disease mechanism research won’t come from a single data point. It will come from integrating high-plex proteomics, single-cell transcriptomics, and high-resolution spatial biology.

As your CRO partner, we provide innovative assay platforms in multiomics for diverse research needs and sample types through Carolina Molecular’s accredited laboratory. We also offer Bioinformatics in-house to answer complex biological questions, from experimental design, to pipeline development, and reporting.

 

An innovative, instrument-free single-cell platform that leverages a novel molecular process called Kinetic Confinement. This thermodynamic approach controls molecular diffusion to enable high-fidelity single-cell indexing in standard, solution-phase reactions within PCR tubes or plates. This scalable workflow generates sequencer-ready 3’ scRNA-Seq libraries in a single day, overcoming the throughput and cost limitations of microfluidic or droplet-based systems.

Learn More: https://csgenetics.com/

A single-cell spatial proteomics assay, based on the Proximity Network Assay (PNA), that maps the cell surface protein interactome. The technology uses DNA-barcoded antibodies to target proteins. When antibodies are in close proximity, their DNA tags are amplified in situ via rolling circle amplification (RCA). A subsequent ligation step forms connections between neighboring RCA products, creating a proximity network that is quantified by NGS. This reveals nanoscale-resolution data on protein-protein interactions, co-localization, and clustering on a cell-by-cell basis.

Learn More: https://phenovista.com/

An advanced, imaging-based approach to functional biology, often utilizing the Cell Painting assay. This method uses a multiplexed palette of fluorescent dyes to “paint” multiple cellular components (e.g., nucleus, mitochondria, cytoskeleton, ER). Automated high-content microscopy captures multi-channel images, and sophisticated image analysis software extracts thousands of quantitative morphological features (size, shape, texture, intensity). This creates a high-dimensional “phenotypic profile” or “fingerprint” for each cell, which is then analyzed using machine learning to functionally characterize drug response or disease states.

Learn More: https://www.pixelgen.com/

A robust and sensitive bead-based immunoassay platform for the simultaneous quantification of up to 80 different proteins (cytokines, chemokines, growth factors, etc.) from a single, low-volume sample (25-50µL).

A powerful spatial biology platform that enables high-plex, spatially-resolved profiling of both RNA and protein from any region of interest (ROI) on a tissue slide. It works with fresh frozen (FF) and FFPE samples, allowing you to unlock data from archived cohorts.

Maximize Your Data

Link cellular phenotypes to molecular signatures, and integrate transcriptomic data with proteomic insights. Maximize the biological insights from clinical specimens through strategic, complementary assay selection.

Preserve Precious Samples

Run multiple assays from minimal input, ensuring you get the most from every irreplaceable clinical sample.

Ask Bigger Questions

Move beyond what is expressed to where it’s expressed, how it’s interacting, and what its functional consequence is.

Accelerate Your Timeline

Our integrated bioinformatics and scientific support teams help you connect the dots, turning complex, multi-omic datasets into a single, actionable report.

Better Answers Through Integrated Technologies

Biomarker Discovery & Validation

Identify candidates through single-cell profiling, validate spatial distribution in tissue, quantify soluble forms in circulation, and link to functional phenotypes.

Disease Mechanism Elucidation

Map cellular neighborhoods spatially, profile transcriptional states at single-cell resolution, measure secreted mediators, and assess surface protein organization.

Therapeutic Target Validation

Confirm target expression and cell-type specificity, validate spatial distribution, assess surface accessibility and protein interactions, and demonstrate functional consequences.

Drug Mechanism of Action

Capture phenotypic responses, profile transcriptional changes at single-cell resolution, measure spatial reorganization, and assess receptor-level protein reorganization.

Immuno-Oncology & Cell Therapy

Characterize cell products through transcriptional and surface protein profiling, map infiltration patterns in tissue, and monitor systemic immune responses.
Talk with an Expert

Your Science is Complex. Partnering With Us is Simple.

We act as a dedicated extension of your lab, guiding you from experimental design to final report.

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Looking for Multiomic Analysis & Data Insights?

Carolina Molecular has the strong background in R&D and bioinformatic expertise to create solutions that work for our customers, in both clinical and translational research applications.

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